Nigrostriatal upregulation of 5‐HT2A receptors correlates with motor dysfunction in progressive supranuclear palsy
Identifieur interne : 002183 ( Main/Exploration ); précédent : 002182; suivant : 002184Nigrostriatal upregulation of 5‐HT2A receptors correlates with motor dysfunction in progressive supranuclear palsy
Auteurs : Maria Stamelou [Allemagne] ; Andreas Matusch [Allemagne] ; David Elmenhorst [Allemagne] ; René Hurlemann [Allemagne] ; Karla M. Eggert [Allemagne] ; Karl Zilles [Allemagne] ; Wolfgang H. Oertel [Allemagne] ; Günter U. Höglinger [Allemagne] ; Andreas Bauer [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-06-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- 5-HT2A serotonin receptor, 5‐HT, 5‐HT2A receptor, Aged, Brain Mapping, Corpus Striatum (metabolism), Corpus Striatum (radionuclide imaging), Dysfunction, Emission tomography, Female, Fluorine Radioisotopes (metabolism), Humans, Ketanserin (analogs & derivatives), Ketanserin (metabolism), Magnetic Resonance Imaging (methods), Male, Middle Aged, Movement Disorders (etiology), Movement Disorders (pathology), Movement Disorders (radionuclide imaging), Nervous system diseases, PET, PSP, Positron emission tomography, Positron-Emission Tomography (methods), Receptor, Serotonin, 5-HT2A (metabolism), Serotonin, Statistics as Topic, Steele‐Richardson‐Olszewski syndrome, Substantia Nigra (metabolism), Substantia Nigra (radionuclide imaging), Supranuclear Palsy, Progressive (complications), Supranuclear Palsy, Progressive (radionuclide imaging), Up-Regulation (physiology), serotonin.
- MESH :
- chemical , analogs & derivatives : Ketanserin.
- chemical , metabolism : Fluorine Radioisotopes, Ketanserin, Receptor, Serotonin, 5-HT2A.
- complications : Supranuclear Palsy, Progressive.
- etiology : Movement Disorders.
- metabolism : Corpus Striatum, Substantia Nigra.
- methods : Magnetic Resonance Imaging, Positron-Emission Tomography.
- pathology : Movement Disorders.
- physiology : Up-Regulation.
- radionuclide imaging : Corpus Striatum, Movement Disorders, Substantia Nigra, Supranuclear Palsy, Progressive.
- Aged, Brain Mapping, Female, Humans, Male, Middle Aged, Statistics as Topic.
Abstract
A dysfunction of multiple neurotransmitter systems is assumed as a neurochemical basis of the akinetic‐rigid syndrome of progressive supranuclear palsy (PSP). In vitro studies have produced conflicting results on the serotoninergic system in PSP. We, therefore, studied the binding potential of the serotonin 2A (5‐HT2A) receptor ligand [18F]altanserin in 8 patients with clinically probable PSP and 13 healthy controls using positron emission tomography. We found an up‐regulation of 5‐HT2A receptors in the substantia nigra and, to a lower degree, in the striatum, while neocortical 5‐ HT2A receptor densities showed no changes upon partial‐volume correction. Nigral and striatal receptor changes were significantly correlated with patients' scores of motor dysfunction (UPDRS III, PSP‐rating scale) pointing to a functional relevance of the described findings. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22533
Affiliations:
- Allemagne
- District de Cologne, District de Giessen, Hesse (Land), Rhénanie-du-Nord-Westphalie
- Bonn, Juliers, Marbourg
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Le document en format XML
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Eggert</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Zilles, Karl" sort="Zilles, Karl" uniqKey="Zilles K" first="Karl" last="Zilles">Karl Zilles</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Neuroscience and Biophysics–Medicine (INB‐3), Research Center Jülich, Jülich</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Juliers</settlement></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>C. & O. Vogt Institute for Brain Research, University of Düsseldorf, Düsseldorf</wicri:regionArea><wicri:noRegion>Düsseldorf</wicri:noRegion><wicri:noRegion>Düsseldorf</wicri:noRegion></affiliation></author><author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Hoglinger, Gunter U" sort="Hoglinger, Gunter U" uniqKey="Hoglinger G" first="Günter U." last="Höglinger">Günter U. Höglinger</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Günter U. Höglinger, Department of Neurology, Philipps University, Rudolf‐Bultmann Str. 8, Marburg 35039, GermanyAndreas Bauer, Institute of Neuroscience and Biophysics–Medicine (, Research Center Jülich, Jülich 52425</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Juliers</settlement></placeName></affiliation></author><author><name sortKey="Bauer, Andreas" sort="Bauer, Andreas" uniqKey="Bauer A" first="Andreas" last="Bauer">Andreas Bauer</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Neuroscience and Biophysics–Medicine (INB‐3), Research Center Jülich, Jülich</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Juliers</settlement></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Düsseldorf, Düsseldorf</wicri:regionArea><wicri:noRegion>Düsseldorf</wicri:noRegion><wicri:noRegion>Düsseldorf</wicri:noRegion></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Günter U. Höglinger, Department of Neurology, Philipps University, Rudolf‐Bultmann Str. 8, Marburg 35039, GermanyAndreas Bauer, Institute of Neuroscience and Biophysics–Medicine (, Research Center Jülich, Jülich 52425</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Juliers</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-06-15">2009-06-15</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1170">1170</biblScope><biblScope unit="page" to="1175">1175</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">C9C7F6F48A73FC841BA75DE92A7EA650E09C4457</idno><idno type="DOI">10.1002/mds.22533</idno><idno type="ArticleID">MDS22533</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>5-HT2A serotonin receptor</term><term>5‐HT</term><term>5‐HT2A receptor</term><term>Aged</term><term>Brain Mapping</term><term>Corpus Striatum (metabolism)</term><term>Corpus Striatum (radionuclide imaging)</term><term>Dysfunction</term><term>Emission tomography</term><term>Female</term><term>Fluorine Radioisotopes (metabolism)</term><term>Humans</term><term>Ketanserin (analogs & derivatives)</term><term>Ketanserin (metabolism)</term><term>Magnetic Resonance Imaging (methods)</term><term>Male</term><term>Middle Aged</term><term>Movement Disorders (etiology)</term><term>Movement Disorders (pathology)</term><term>Movement Disorders (radionuclide imaging)</term><term>Nervous system diseases</term><term>PET</term><term>PSP</term><term>Positron emission tomography</term><term>Positron-Emission Tomography (methods)</term><term>Receptor, Serotonin, 5-HT2A (metabolism)</term><term>Serotonin</term><term>Statistics as Topic</term><term>Steele‐Richardson‐Olszewski syndrome</term><term>Substantia Nigra (metabolism)</term><term>Substantia Nigra (radionuclide imaging)</term><term>Supranuclear Palsy, Progressive (complications)</term><term>Supranuclear Palsy, Progressive (radionuclide imaging)</term><term>Up-Regulation (physiology)</term><term>serotonin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Ketanserin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Fluorine Radioisotopes</term><term>Ketanserin</term><term>Receptor, Serotonin, 5-HT2A</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Movement Disorders</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Corpus Striatum</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Imaging</term><term>Positron-Emission Tomography</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Movement Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Up-Regulation</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Corpus Striatum</term><term>Movement Disorders</term><term>Substantia Nigra</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Brain Mapping</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Statistics as Topic</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Pathologie du système nerveux</term><term>Récepteur sérotoninergique 5-HT2A</term><term>Sérotonine</term><term>Tomographie par émission de positons</term><term>Tomoscintigraphie</term><term>Trouble fonctionnel</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A dysfunction of multiple neurotransmitter systems is assumed as a neurochemical basis of the akinetic‐rigid syndrome of progressive supranuclear palsy (PSP). In vitro studies have produced conflicting results on the serotoninergic system in PSP. We, therefore, studied the binding potential of the serotonin 2A (5‐HT2A) receptor ligand [18F]altanserin in 8 patients with clinically probable PSP and 13 healthy controls using positron emission tomography. We found an up‐regulation of 5‐HT2A receptors in the substantia nigra and, to a lower degree, in the striatum, while neocortical 5‐ HT2A receptor densities showed no changes upon partial‐volume correction. Nigral and striatal receptor changes were significantly correlated with patients' scores of motor dysfunction (UPDRS III, PSP‐rating scale) pointing to a functional relevance of the described findings. © 2009 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>District de Cologne</li><li>District de Giessen</li><li>Hesse (Land)</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Bonn</li><li>Juliers</li><li>Marbourg</li></settlement></list><tree><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Stamelou, Maria" sort="Stamelou, Maria" uniqKey="Stamelou M" first="Maria" last="Stamelou">Maria Stamelou</name></region><name sortKey="Bauer, Andreas" sort="Bauer, Andreas" uniqKey="Bauer A" first="Andreas" last="Bauer">Andreas Bauer</name><name sortKey="Bauer, Andreas" sort="Bauer, Andreas" uniqKey="Bauer A" first="Andreas" last="Bauer">Andreas Bauer</name><name sortKey="Bauer, Andreas" sort="Bauer, Andreas" uniqKey="Bauer A" first="Andreas" last="Bauer">Andreas Bauer</name><name sortKey="Eggert, Karla M" sort="Eggert, Karla M" uniqKey="Eggert K" first="Karla M." last="Eggert">Karla M. Eggert</name><name sortKey="Elmenhorst, David" sort="Elmenhorst, David" uniqKey="Elmenhorst D" first="David" last="Elmenhorst">David Elmenhorst</name><name sortKey="Hoglinger, Gunter U" sort="Hoglinger, Gunter U" uniqKey="Hoglinger G" first="Günter U." last="Höglinger">Günter U. Höglinger</name><name sortKey="Hoglinger, Gunter U" sort="Hoglinger, Gunter U" uniqKey="Hoglinger G" first="Günter U." last="Höglinger">Günter U. Höglinger</name><name sortKey="Hurlemann, Rene" sort="Hurlemann, Rene" uniqKey="Hurlemann R" first="René" last="Hurlemann">René Hurlemann</name><name sortKey="Matusch, Andreas" sort="Matusch, Andreas" uniqKey="Matusch A" first="Andreas" last="Matusch">Andreas Matusch</name><name sortKey="Matusch, Andreas" sort="Matusch, Andreas" uniqKey="Matusch A" first="Andreas" last="Matusch">Andreas Matusch</name><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name><name sortKey="Stamelou, Maria" sort="Stamelou, Maria" uniqKey="Stamelou M" first="Maria" last="Stamelou">Maria Stamelou</name><name sortKey="Zilles, Karl" sort="Zilles, Karl" uniqKey="Zilles K" first="Karl" last="Zilles">Karl Zilles</name><name sortKey="Zilles, Karl" sort="Zilles, Karl" uniqKey="Zilles K" first="Karl" last="Zilles">Karl Zilles</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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